A score test for linkage analysis of ordinal traits based on IBD sharing
نویسندگان
چکیده
منابع مشابه
A score test for linkage analysis of ordinal traits based on IBD sharing.
Statistical methods for linkage analysis are well established for both binary and quantitative traits. However, numerous diseases including cancer and psychiatric disorders are rated on discrete ordinal scales. To analyze pedigree data with ordinal traits, we recently proposed a latent variable model which has higher power to detect linkage using ordinal traits than methods using the dichotomiz...
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SUMMARY Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance pattern...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2007
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxm016